Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotype
نویسندگان
چکیده
منابع مشابه
Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotypes
OBJECTIVE This study aimed to investigate the clinical characteristics and prognostic significance of monosomal karyotypes (MKs) in patients with acute myeloid leukemia (AML). MATERIALS AND METHODS We retrospectively analyzed the clinical data for 498 patients with AML, of whom 233 (46.8%) had an abnormal karyotype, including 42 with MKs (8.4%) and 70 with a complex karyotype (CK) (14.1%). ...
متن کاملBlood consult: monosomal karyotype acute myeloid leukemia.
A 24-year-old woman presented to her primary care physician for persistent bilateral otitis media and frequent night sweats. Laboratory evaluation revealed a white blood cell count of 26 000/mL with 84% blasts on differential, hemoglobin 6.8 g/dL, and platelet 90 000/mL. Her total serum lactate dehydrogenase level was 888 U/L. She underwent a diagnostic bone marrow aspirate and biopsy, which de...
متن کاملCytogenetic Profile of Monosomal Karyotype in Adult Acute Myeloid Leukemia
Cytogenetic abnormalities at diagnosis are important prognostic indicators in acute myeloid leukemia (AML). AML is categorized into 3 risk groups according to cytogenetic abnormalities; favorable, intermediate, and unfavorable. A new cytogenetic risk group called the monosomal karyotype (MK) had been identified in AML in the unfavorable cytogenetic risk group. The MK was reported to be associat...
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A 24-year-old woman presented to her primary care physician for persistent bilateral otitis media and frequent night sweats. Laboratory evaluation revealed a white blood cell count of 26 000/mL with 84% blasts on differential, hemoglobin 6.8 g/dL, and platelet 90 000/mL. Her total serum lactate dehydrogenase level was 888 U/L. She underwent a diagnostic bone marrow aspirate and biopsy, which de...
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ژورنال
عنوان ژورنال: Turkish Journal of Hematology
سال: 2017
ISSN: 1300-7777
DOI: 10.4274/tjh.2016.0255